Affliction

Affliction is a stacking debuff that reduces Maximum Hitpoints by 1% per stack and has a maximum stack size of 50.

While there is nothing which provides a chance to ignore affliction, reducing the enemy's hit chance is a useful method of minimizing the amount of affliction stacks applied. For this the protection prayers ( Protect from Magic, Protect from Ranged, and Protect from Melee) are particularly useful.