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This page briefly documents all combat debuffs and provides links to more elaborate explanations of each.
Affliction
Affliction is a stacking debuff that reduces your Maximum Hitpoints by 1% per stack and has a maximum stack size of 50.
While there is nothing which provides a chance to ignore affliction, reducing the enemy's hit chance is a useful method of minimizing the amount of affliction stacks applied. For this the protection prayers (
Protect from Magic, 
Protect from Ranged, and 
Protect from Melee) are particularly useful.
Barrier Burn
Barrier Burn is an effect which gradually depletes the 
Barrier of Monsters over time.
Bleed
Bleed is a Damage Over Time effect that deals damage over 10 seconds. Bleed damage depends on the weapon inflicting the bleed. Bleeds cannot be refreshed or overwritten until the existing bleed expires.
Burn
Burn is a Damage Over Time effect that deals 15% of the target's Current HP over 2.5 seconds.
Freeze
Freeze is an effect that prevents the target from attacking. While the target is frozen, hits against the target cannot miss and deal 30% increased damage. One stack of freeze is removed after the target completes an attack turn.
Frostburn
Frostburn is an effect that slows the target by 10% for 3 turns and causes the target to take 3% of Current HP per attack.
Poison
Poison is a Damage Over Time effect that comes in two flavours:
- Poison, which deals 10% of the target's maximum
HP over 10 seconds.
- Deadly Poison, which deals 25% of the target's maximum HP over 10 seconds.
Despite the name, deadly poison isn't an effect that has a realistic chance of killing the player, provided they have sufficient Food and have purchased 
Auto Eat.
Shock
Shock is an effect which reduces the Damage Reduction (DR) of the target by a flat 2% each time they are hit. The attack can stack up to 10 times, resulting in up to a 20% reduction of the target's DR.
As with #Affliction, the only way to reduce the chance of being shocked is to reduce the enemy's chance to hit as much as possible.
Sources
The effect can be inflicted by any of the monsters within the 
Lightning Region dungeon:
Sleep
Sleep is an effect that prevents the target from attacking. While the target is asleep, hits against the target cannot miss and deal 20% increased damage. One stack of sleep is removed after the target completes an attack turn.
Slow
Slow is an effect which increases the amount of time taken between the target's attacks.
Stun
Stun is an effect that prevents the target from attacking. While the target is stunned, hits against the target cannot miss and deal 30% increased damage. One stack of stun is removed after the target completes an attack turn.
The chance to ignore stuns is a separate roll from the chance to be stunned (as opposed to being a flat reduction to the stun chance). Considering the chance to ignore stuns, the effective chance to be stunned is [math]\displaystyle{ \frac{\text{Stun Chance}}{100} \times \left (1 - \frac{\text{Chance to Ignore Stuns}}{100} \right ) \times 100\% }[/math].
Toxin
Eldritch Curse
Ablaze
Voidburst
Fear
Laceration
Blight
Silence
Wither
Combat:
