Curses

From Melvor Idle

Curses inflict the enemy with debuffs, making them weaker in a variety of ways. They are automatically cast alongside the active damage-dealing spell every three attack turns, and do not take any extra time to cast (but do consume Runes). Curses can be used with Standard Magic, Auroras, and Archaic Magicks, but cannot be used with Ancient Magicks.

The Miolite Sceptre allows Curses to be cast while using the
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Melee
combat style, and the Voodoo Trinket allows Curses to be cast with any combat style.